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Molecular sieves are materials with pores of uniform size and diameter that are similar in size to small molecules; used to separate molecules by size; available in various pore size ranges, with drying solvent indicators, etc.
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Recombinant semaphorin-3A (SEMA3A) is a secreted axon guidance and cell-signaling protein supplied as a research reagent. The product is provided as a small purified preparation intended for in vitro assays, cell biology studies, and biochemical characterization. Purity is reported by the manufacturer as greater than 95% by reducing SDS-PAGE.
Recombinant protein suitable for research use only.
Expressed in HEK293 cells to support eukaryotic post-translational modifications.
Fc-tagged format to aid detection and dimerization where applicable.
Purity greater than 95% as determined by reducing SDS-PAGE.
Supplied in a small, lyophilized preparation for convenient storage.
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
TCS-PIM-1-4a is a small-molecule inhibitor targeting Pim kinases a family of serine/threonine kinases It is designed to selectively inhibit Pim kinases thereby modulating signaling pathways related to cell growth and survival TCS-PIM-1-4a exerts its biological activity primarily through activation of AMP-activated protein kinase (AMPK) resulting in inhibition of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway In cell-based studies TCS-PIM-1-4a demonstrates cytotoxic activity against diverse hematological tumor cell lines including myeloid and lymphoid subtypes with IC50 values ranging from approximately 0 8 to 40 M Based on these pharmacological properties TCS-PIM-1-4a holds research potential in investigations of Pim kinase signaling and therapeutic strategies for hematological malignancies
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
SMI-4a (CAS 438190-29-5) is a selective inhibitor of the serine/threonine kinase Pim-1 exhibiting an IC50 of 17 nM Pim-1 is implicated in the regulation of cell cycle progression and apoptosis with its overexpression associated with enhanced cell survival in various malignancies SMI-4a demonstrates increased activity compared to related compounds and inhibits downstream mTORC1 signaling and activates AMPK in leukemia cell lines leading to cell cycle arrest and apoptosis induction In preclinical studies SMI-4a reduced tumor volume in xenograft mouse models highlighting its utility for investigating Pim kinase-driven pathways in cancer research
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More